The purpose of this study was to develop a nanosuspension of a poorly soluble drug by nanomilling process using pearl milling technique to achieve superior in vitro dissolution and high in vivo absorption of drug. A promising simvastatin nanosuspension was formulated with poloxamer-407 as a stabilizer and Zirconium Oxide beads as a milling media. The obtained nanosuspension having particle size in the nano range (333nm) which is characterized by particle size , Zeta potential and Screening Electron Microscopy (SEM) method. This formed nanosuspension was lyophilized. Although the formulation showed significant improvement during in vitro dissolution as compared to pure drug and its marketed formulations. The in vivo study revels that the decrease in the total cholesterol level increases high-density lipoprotein cholesterol. Probably due the formation of nanoparticles which absorbs rapidly. The stability study was carried out at two different temperature and its shows that the lyophilized simvastatin nanosuspension was stable up to six month.
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